Synthesis of Intermediate N-Chloroformyl-N-[4-(trifluoromethoxy) phenyl] Methyl Carbamate of Indoxacarb

更新时间:2023-05-28

【摘要】[Objective] The paper was to study a synthetic method suitable for industrial production of intermediate N-Chloroformyl-N-[4-(trifluoromethoxy) phenyl] methyl carbamate of indoxacarb. [Method] Using 4-trifluoromethoxy aniline as the starting material, [4-(trifluoromethoxy) phenyl]carbamate was synthesized by homogeneous formylation method without acid-binding agent. Subsequently, it was reacted with sodium methoxide/potassium methoxide by reactive distillation to obtain [4-(trifluoromethoxy) phenyl] carbamate ammonium sodium/potassium, then directly reacted with triphosgene to obtain crude products of N-carbonochloridoyl-N-[4-(trifluoromethoxy) phenyl] carbamate; finally, competing product was obtained by recrystallization. [Result] The intermediate N-chloroformyl-N-[4-(trifluoromethoxy) phenyl] carbamate was synthesized by the method. The content of products was higher than 98%.The yield of product reached above 96%(calculated by 4-trifluoromethoxy aniline). [Conclusion] The method used for the synthesis of intermediate N-chloroformyl-N-[4-(trifluoromethoxy) phenyl] methyl carbamate was simple, with less three wastes, higher safety and lower cost.

【关键词】

阅读全文